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Two-pronged phage treatment counters resistance in Mycobacterium abscessus lung infections

07.05.2026

Two-pronged phage treatment counters resistance in Mycobacterium abscessus lung infections

A new study on Mycobacterium abscessus has revealed an important detail: bacteria can "escape" even bacteriophages—the viruses that destroy them. In response to phage therapy, they change their shape or mutate, making treatment less effective. This is especially relevant against the backdrop of rising antimicrobial resistance, when conventional antibiotics are increasingly ineffective. But there's good news: scientists have found a solution—combination phage therapy—that simultaneously targets different bacterial variants.

#antibiotics #combination therapy #mutants

Bacterial viruses “overheard” signals from other species about hibernation. It hurt themselves

29.04.2026

Bacterial viruses “overheard” signals from other species about hibernation. It hurt themselves

Bacterial viruses have proven capable of reading chemical signals from other species indicating how many bacteria are still available for capture, and using this information to decide whether to enter dormancy or actively replicate. However, this "eavesdropping" is only useful for the viruses that produce these chemical signals themselves, not for those that read them. Since bacterial viruses are being explored as a means of combating antibiotic-resistant infections, the ability to influence the behavior of these viruses will improve the effectiveness of such measures.

#lysis #peptide #lysogeny

How modern phage therapy works: genetically improved phages and new ways to monitor their action

24.04.2026

How modern phage therapy works: genetically improved phages and new ways to monitor their action

Today, phage therapy is no longer just an alternative to antibiotics, but a new approach to fighting infections. It combines biology, genetics, and modern technology, opening the door to treatments that until recently seemed impossible. If this field continues to develop, humanity may have a powerful answer to the challenge posed by the era of antibiotic resistance.

#CRISPR-Cas #giant phages #bioimaging

Invisible to bacteria: scientists have discovered a new trick of bacteriophages

16.04.2026

Invisible to bacteria: scientists have discovered a new trick of bacteriophages

Scientists describe a new mechanism that demonstrates the complexity of the "battle" between viruses and bacteria. The bacteriophage in question is HY126, which has a specialized enzyme system in its genome that modifies viral DNA. This mechanism involves two sequential chemical modifications of cytosine, one of the DNA bases: hydroxylation and the subsequent addition of arabinose molecules. This discovery expands our understanding of phage biology and reveals new ways in which viruses evade bacterial defenses.

#DNA #enzyme #cytosine

Bacteriophage W5 isolated from wastewater and waste is a new weapon against Salmonella

09.04.2026

Bacteriophage W5 isolated from wastewater and waste is a new weapon against Salmonella

A novel bacteriophage isolated from slaughterhouse wastewater and poultry farm effluent could be the key to protecting against Salmonella poisoning.

#salmonella #bacteria #wastewater

Care through science: Sabour Awards for students researching bacteriophages and food safety

01.04.2026

Care through science: Sabour Awards for students researching bacteriophages and food safety

Sometimes a person’s legacy is not just their scientific achievements, but also the light they light in others. Professor Parviz Sabour was just such a person: an outstanding microbiologist, educator, and science communicator who dedicated his life to the study of bacteriophages and food safety. After his death, his family fulfilled his dream by establishing the Sabour Graduate Awards to support young scientists working in these important areas.

#award #scientist #science

Mutant organisms from space could solve the global antibiotic crisis

25.03.2026

Mutant organisms from space could solve the global antibiotic crisis

Scientists have studied how bacteriophages behave in microgravity conditions on the International Space Station. Although infection progresses significantly more slowly there, the process itself doesn't stop—phages still find a way to infect bacteria and reproduce.

#ISS #International Space Station #infection

First fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa

17.03.2026

First fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa

Scientists literally "assembled" a phage from 28 synthetic DNA fragments and were even able to program its behavior.

#engineering #design #system

Stunning High-Resolution Virus Blueprint Offers New Hope Against Antibiotic Resistance

10.03.2026

Stunning High-Resolution Virus Blueprint Offers New Hope Against Antibiotic Resistance

A detailed 3D map of a bacteria-hunting virus reveals ancient origins and new promise against superbugs.

Synthetic bacteriophages against antibiotic-resistant bacteria

28.01.2026

Synthetic bacteriophages against antibiotic-resistant bacteria

Scientists have developed the first fully synthetic method for building and reprogramming bacteriophages, offering a faster and safer route to designing virus-based treatments for drug-resistant bacteria.

Locus Biosciences receives $3.3 million for clinical trial of AI-powered phage therapy to treat pneumonia

08.01.2026

Locus Biosciences receives $3.3 million for clinical trial of AI-powered phage therapy to treat pneumonia

The Phase 1b clinical trial of LBP-PA01 will enable Locus to evaluate safety, efficacy, and optimal dosing in patients with P. aeruginosa infections that are becoming increasingly difficult to treat with conventional antibiotics.

#artificial intelligence #АІ #lungs

Phage therapy in Belgium

08.02.2022

Phage therapy in Belgium

Since 2019, Belgium has approved the use of bacteriophages to treat antibiotic-resistant infections. More than 100 patients have already undergone treatment with bacterial viruses. The clinical case of one of them is described in the latest issue of the journal Nature Communications.

#phage therapy #multi-resistant bacteria

More than a million deaths each year are linked to antibiotic resistance

15.01.2022

More than a million deaths each year are linked to antibiotic resistance

American scientists analyzed data from around the world for 2019 and showed that hundreds of thousands of people die annually from bacterial infections that were previously successfully treated with antibiotics but are now resistant to them.

#antibiotic resistance #multidrug-resistant bacteria

Aminoglycoside antibiotics can inhibit bacteriophages

21.12.2021

Aminoglycoside antibiotics can inhibit bacteriophages

Secondary metabolites of some bacteria are antibiotics, meaning they can exert antibacterial activity. However, they can also have antiviral properties and suppress phage infection.

#phage therapy

Antibiotics in animal husbandry: is there an alternative?

14.12.2021

Antibiotics in animal husbandry: is there an alternative?

The use of antibiotics has become the norm in modern animal husbandry, as these drugs not only help prevent bacterial infections in animals but also contribute to their weight gain. The result is the spread of antibiotic resistance.

#antibiotic resistance #multidrug-resistant bacteria

Phage therapy saves rare animals

08.12.2021

Phage therapy saves rare animals

A combination of bacteriophage and antibiotic treatment has resulted in significant improvement in the condition of a sea turtle that had suffered from a chronic bacterial shell infection resistant to most antimicrobial agents for four years.

#phage therapy #multi-resistant bacteria

Ukraine will collect data on antibiotic resistance

29.11.2021

Ukraine will collect data on antibiotic resistance

Now, data collection on antibiotic resistance can be carried out by medical institutions providing specialized or highly specialized medical care, as well as independent bacteriological laboratories.

#antibiotic resistance #multidrug-resistant bacteria

Phage-like particles as a platform for rapid vaccine creation

19.11.2021

Phage-like particles as a platform for rapid vaccine creation

A monovalent vaccine based on phage-like particles carrying SARS-CoV-2 virus antigens ensures the synthesis of neutralizing antibodies, long-lasting and effective protection against infection

#coronavirus #immune system

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