Suppurative inflammatory diseases of the ear, throat, and nose typically develop as complications following an acute respiratory viral infection (ARVI). Ear, throat, and nose diseases are often caused by opportunistic bacteria—staphylococci, streptococci, Pseudomonas aeruginosa, and others. These bacteria inhabit the mucous membranes of the respiratory tract in almost everyone and cause disease only when the immune system is weakened (particularly during ARVI). Opportunistic bacteria often exhibit multiple antibiotic resistance. The use of bacteriophages in the treatment of inflammatory diseases of the ear, throat, and nose not only eliminates the infection but also stimulates the body's own immune response.

 

If a runny nose persists for more than 10 days, accompanied by yellow-green nasal discharge, headache, photophobia, and lacrimation, there is reason to suspect acute purulent sinusitis—a bacterial infection of the paranasal sinuses. In sinusitis, the narrow openings connecting the nasal cavity and paranasal sinuses become almost completely blocked due to inflammation of the swollen mucous membrane. Discharge from the sinuses stops draining, and ventilation and drainage are impaired, creating favorable conditions for bacterial proliferation and increased inflammation. Air, along with pus or other discharge, puts pressure on the sinus walls, causing pain, while bacterial toxins and tissue breakdown products are absorbed through the mucous membranes of the paranasal sinuses into the bloodstream, leading to general intoxication of the body.

 

Without adequate treatment, these conditions can become chronic and cause complications in internal organs. Patients with chronic sinusitis are significantly more likely to experience bronchitis and pneumonia.

 

Treatment of purulent sinusitis involves reducing nasal mucosal congestion and draining mucus from the sinuses, as well as antibacterial therapy. To eliminate the infection, it is advisable to use medications containing bacteriophages that lyse the most common pathogens causing purulent sinusitis, in particular, Pyofag®. Phage preparations are highly specific—they destroy pathogenic bacteria without affecting the beneficial microflora of the oral cavity and intestines. Due to its high safety, Pyofag® is approved for use in children (see instructions ). Furthermore, bacteriophages stimulate specific and nonspecific immune factors, which is especially important in the treatment of chronic inflammatory diseases in weakened patients.

 

The drug Pyofag® is used for sinusitis both locally and orally.

 

For topical application, use cotton swabs soaked in the bacteriophage solution (undiluted). The swabs are inserted into the nasal passages after rinsing the sinuses and left in place for 1 hour. Swabs are changed up to 3 times a day. For nasal irrigation, the solution is diluted in boiled water at room temperature in a 1:3 ratio, i.e., 10 ml of solution to 30 ml of water.
The drug is taken orally 3 times a day, according to the age dose, 1 hour before meals for 7-20 days.

 

For age-specific dosages of the drug, see the Instructions for medical use of the medicinal product Pyofag®.

 

Ear pain, hearing loss, and fever may indicate the onset of otitis. Viral otitis, if left untreated, can develop into a purulent form. The most common form of otitis is inflammation of the middle ear. Bacteria enter the ear from the nasopharynx during a runny nose or pharyngitis; they can be carried into the auditory tube by the bloodstream and lymph. In childhood, inflammation and enlargement of the adenoids can lead to blockage of the middle ear opening, impairing its natural ventilation. With bacterial otitis, pus accumulates in the middle ear cavity and distends the eardrum. The pain intensifies and begins to radiate to the temple area. Pus can rupture the eardrum and leak out. If the pus has no outlet, the infection can spread to adjacent tissues (inner ear, meninges, trigeminal nerve), leading to hearing loss.

 

Treatment of purulent otitis involves reducing mucosal swelling and restoring normal communication between the nasal cavity and middle ear. Anti-inflammatory and analgesic medications are administered both topically in the form of drops and systemically. Antibacterial therapy is the mainstay of treatment for purulent otitis. An effective and safe option is phage therapy—treatment with bacteriophages that lyse the most common pathogens causing purulent otitis, specifically Pyofag®. Phage preparations destroy pathogenic bacteria without affecting beneficial microflora. Pyofag® is approved for use in children (see instructions ). Bacteriophages stimulate the immune system, which is especially important in the treatment of chronic inflammatory diseases.

 

The drug Pyofag® for otitis is used locally and also orally.

 

For topical application, use cotton swabs soaked in the bacteriophage solution (undiluted). The swabs are inserted into the ear canal and left in place for 1 hour. The swabs are changed up to 3 times a day. The medication is taken orally, at the appropriate age dose, 3 times daily, 1 hour before meals for 7-20 days.

 

For age-specific dosages of the drug, see the Instructions for medical use of the medicinal product Pyofag®.

 

A severe sore throat with a sudden rise in body temperature to 38–39°C (100.4–102.5°F), headache, weakness, and the appearance of yellow pustules or a gray-white coating on the tonsils—this is how a sore throat (acute tonsillitis) typically begins. Most often, a streptococcal infection is the cause. For various reasons (improper treatment, weakened immunity), acute tonsillitis can become chronic, with persistent inflammation in the throat that periodically flares up. Furthermore, bacteria colonizing the tonsils secrete toxic products that can gradually lead to the development of rheumatism, myocarditis, arthritis, glomerulonephritis, and other conditions.

 

Treatment for tonsillitis includes bed rest, drinking plenty of fluids, and antibacterial therapy, both local and systemic. Bacteriophages, particularly Pyofag®, are a useful addition to the treatment regimen for tonsillitis. These phage preparations target only pathogenic bacteria, leaving the normal microflora intact and without causing dysbiosis. Additionally, bacteriophages stimulate the immune system. Pyofag® is approved for use in children (see instructions ).

 

The drug Pyofag® for otitis is used locally and also orally.

 

The medicine is used as a gargle 3-4 times daily at a dose of 10-20 ml, as well as for targeted tonsil irrigation. The medicine is taken orally at the appropriate age dose 3 times daily 1 hour before meals for 7-20 days.

 

 

Download the instructions for medical use of the medicinal product Pyofag®

 

R.P. No. UA/15974/01/01. Approved by Order of the Ministry of Health of Ukraine No. 478 dated April 28, 2017.

 

Information about this medication is provided for informational purposes only and should not be used as a guide to self-medication. Only a physician can prescribe this medication, as well as determine the dosage and method of administration.