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Phage-specific effects on the immune system

Andrzej Górski, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Maciej Żaczek, and Jan Borysowski.

Phage-specific diverse effects of bacterial viruses on the immune system

Future Microbiol., 2019, 14(14): 1171–1174. doi: 10.2217/fmb-2019-0222

"...As the struggle to register phage as a medicinal product and to introduce it onto the market continues, parallel data have been accumulating to indicate that phage may interact not only with bacteria but also with eukaryotic cells (including cells of the immune system). Therefore, it cannot be excluded that in the future, after phage discovery, research may shift towards phage–immune system interactions, whereas, to date, work on phage interactions with their natural target (bacteria) has prevailed. Hopefully, simultaneous advancements in both research fields can bring beneficial results for human health, both in terms of combating antibiotic-resistant bacterial infections and developing novel anti-inflammatory and immunomodulatory agents with minimal toxicity and satisfactory efficacy..."