In light of the novel coronavirus, scientists and researchers from all over the globe have been looking at traditional and non-traditional methods to develop a vaccine or treatment, some have led towards bacteriophages and Covid19.
Bacteriophage DNA-based nasal spray
At the University of Waterloo in Canada, researchers are in the process of developing a nasal DNA-based vaccine, which uses phage as a vector. The idea behind this vaccine is to stimulate an immune response in the nasal cavity and targeted cells in the respiratory tract. The DNA will trigger the production of a virus-like particle (VLP) that will induce an immune response. The VLP would attach itself onto the location which the Covid19 would normally bind to, resulting in the limitation of sites for potential transmission.
Researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Freie Universität Berlin, Technische Universität Berlin (TU), Humboldt-Universität (HU), the Robert Koch Institute (RKI) and Charité-Universitätsmedizin Berlin, have chemically modified a bacteriophage capsid, that restrains a variety of viruses. During their research, it was observed that certain respiratory viruses were enveloped by the bacteriophage capsids, resulting in them become unable to infect lung cells. The results of this study are also being looked at the help battle the current situation with Covid19.
Fighting secondary bacterial infections
No recommendations have been looked at for the use of bacteriophages in the prevention of secondary bacterial pneumonia and sepsis that occurred in some patients. The bacteria that begin to manifest during lung injury and the presence of the cytokine storm, is still a prominent problem that has not been addressed. Lytic bacteriophages against such bacterial infection when using an inhalation method would be worth exploring. In addition, any prophylactic lytic phages have immunomodulatory effects that would be helpful for the prevention of cytokine reaction from the start.
Read with more details here: https://www.bacteriophage.news/bacteriophages-and-covid19