• Bacteriophages are applied in treatment of stomatitis.
  • Bacteriophages are applied locally (rinsing, applications) and orally (oral administration).
  • Bacteriophages are applied in case of multi-resistance of causative bacteria to antibiotics.
  • Bacteriophages are applied in treatment of patients with intolerance to antibiotics or contraindications of use thereof.
  • Bacteriophages may be used in combination with the other antimicrobial agents.
  • Bacteriophages may be used for prevention of  stomatitis recurrence  in the risk groups: in elderly people, patients with allergies, immunity compromised patients, patients with chronic diseases.


Pain and burning in the mouth, redness and swelling of oral mucosa followed by appearance of aphthaes (small round-shaped formations with distinct vermilion border and grey-yellow plaque in the centre), excessive salivation, bad breath – these symptoms are characteristic of stomatitis. In severe cases the disease may be accompanied by fever, headache, and other symptoms of general intoxication.  Often the pain in mouth disturbs eating. Without an adequate treatment the stomatitis can transform into a recurrent chronic form.


There are various causes of stomatitis: Причины развития стоматита разнообразны: insufficient oral hygiene, allergic reactions, oral mucosa traumatizing with dental prosthesis or sharp edges of teeth, dental problems, herpes virus, fungal infection, digestive system diseases or cardiovascular diseases, diabetes, etc. In case of viral, fungal, or traumatic stomatitis the pathologic process exacerbates a few days after the onset of the disease by secondary bacterial infection, first of all by opportunistic pathogenic bacteria inhabiting the mucous membrane of mouth.


The main task in treatment of stomatitis is to provide disinfection of the oral cavity, eliminate the pain and inflammation, and prevent spreading of the infection. For prevention and treatment of the bacterial stomatitis it is reasonable to use the bacteriophage products, in particular Pyophage ® medicinal product. The bacteriophages contained in it lyze the most common causative agents of pyoinflammatory diseases of oral cavity.


In case of stomatitis Pyophage ® medicinal product is applied locally as well as orally.


The product is used to wash the mouth 3-4 times a day in the amount of 10-20 ml, as well as for applications: gauze wipe soaked in bacteriophage is applied on the area of inflammation 2 times a day.

The product is applied orally according to the age dose 3 times a day 1 hour before meals during 7-20 days.


  • For the age doses of the product refer to the Instructions for medical use of Pyophage ® medicinal product.
  • Full information on the product is contained in the Instructions for medical use.
  • Before use read the Instructions for medical use of Pyophage ® medicinal product.


Download the Instructions for medical use of Pyophage ® medicinal product  


Р.С. № UA/15974/01/01. Approved by the Order of the Ministry of Public Health of Ukraine No. 478 of  28.04.2017.


The information on the product is presented for information purposes only and shall not be used as a guide for self-treatment. Only a doctor can make a decision as to prescribing of the product, as well as doses thereof and method of administration.