Acute enteric infection

Acute enteric infection

  • Bacteriophages are applied in prevention and treatment of acute enteric infections, salmonellosis, shigellosis, dysbacteriosis.
  • Bacteriophages are applied orally and rectally (in enemas).
  • Bacteriophages are applied in case of multi-resistance of causative bacteria to antibiotics.
  • Bacteriophages are applied in treatment of patients with intolerance to antibiotics or contraindications of use thereof.
  • Bacteriophages can be applied in combination with probiotics, enzymatic agents, enteric antiseptics and antibiotics, but they should not be applied with gastrointestinal adsorbents.
  • Bacteriophages are used for prevention of enteric infections in the epidemic focuses (shigellosis, salmonellosis) in children in organized groups, food industry enterprises personnel, waterworks and public utilities, etc.


Acute enteric infection is an inflammation of stomach and intestine induced by a viral or bacterial infection. The disease comes out in diarrhoea (loose stool over 3 times a day), pain in the abdomen, sometimes – nausea, vomiting, and fever. The viral enteric infections are more frequent in autumn and winter, and the bacterial ones – in summer. The contagion takes place through contact or infected food, water, dirty hands. The acute enteric infections are particularly dangerous for infants, who suffer rapid dehydration due to diarrhoea.  Mind that dehydration in children is a subject to urgent hospitalization. Restoration of the fluid-and-electrolyte balance is a crucial task in treatment of acute enteric infection in children, as well as in adults (the optimal solution is applying of rehydration solutions which can be acquired in a drug-store). Besides, a soft diet and use of adsorbents is prescribed. An important element in treatment of acute enteric infections is elimination of the causative agent of the disease.


Although over a half of the acute enteric infections are induced by viruses, in a few days after the onset of the disease due to the inflammation of the intestines the microflora contents is disturbed due to excessive growth of the opportunistic pathogenic bacteria (staphylococci, proteus, coliform bacteria, Pseudomonas Aureginosa, etc.) – a so-called dysbiotic disorders (dysbacteriosis). Opportunistic pathogenic bacteria are the microorganisms practically always inhabiting the mucous membranes of humans but causing damage only when the body defences weaken. The activation of the opportunistic pathogenic enteric flora can considerably slow down the recovery after an acute enteric infection. Therefore, the antibacterial therapy may be reasonable for treatment of viral enteric infections as well. 


Antibiotics are prescribed in case of acute enteric infections only in the most severe cases (cholera, invasive enteric infections). Typically the so-called enteric antiseptics are used – the products acting only in the intestinal lumen and not absorbed in the blood stream, however these products are not always effective. Bacteriophages are an alternative to the traditional antibacterial products.


The bacteriophages are highly specific – they affect only the definite kinds of pathogenic and opportunistic pathogenic bacteria leaving the useful microflora untouched, so they don’t result in development of dysbacteriosis. Besides, the risk of resistance development in the pathogenic bacteria to this type of products is minimal. Due to a high margin of safety bacteriophages are approved for use in children. Applying of bacteriophages stimulates the specific and non-specific immunity factors, which is crucial in case of immunity compromised patients treatment, chronic inflammatory diseases, and in case of bacterial disease carriers.


Moreover, due to a high margin of safety bacteriophages are applied for prevention in case of enteric diseases epidemics (shigellosis, salmonellosis).


Intestiphage ® or Pyophage ® products are applied in case of acute enteric infections orally and rectally. The product is applied orally according to the age dose 3 times a day 1 hour before meals during 7-20 days. It is also possible to apply the product rectally in the form of enemas – according to the age dose 1 time a day after defecation instead of 1 oral administration.


As a preventive measure bacteriophage is administered orally according to the age dose 1 time a day 1 hour before meals. The duration of the course depends on the epidemic situation.


  • For the age doses of the product refer to the Instructions for medical use of Pyophage ® and Intestiphage ® medicinal products.
  • Full information on the products is contained in the Instructions for medical use.
  • Before use read the Instructions for medical use of Pyophage ® and Intestiphage ® medicinal product.


Download the Instructions for medical use of Pyophage ® medicinal product  

Download the Instructions for medical use of Intestiphage ® medicinal product  


Pyophage ® Р.С. № UA/15974/01/01. Approved by the Order of the Ministry of Public Health of Ukraine No. 478 of  28.04.2017.
Intestiphage ® Р.С. № UA/15970/01/01. Approved by the Order of the Ministry of Public Health of Ukraine No. 478 of  28.04.2017.


The information on the product is presented for information purposes only and shall not be used as a guide for self-treatment. Only a doctor can make a decision as to prescribing of the product, as well as doses thereof and method of administration.